Correction: The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
Sixtine Fleury, Katherine M. Nautiyal
Molecular Psychiatry February 12, 2026 correction DOI: 10.1038/s41380-026-03488-5 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study |
|---|---|
| Population | Mice |
| Intervention | psilocybin |
| Topics | Psilocybin Serotonin |
| Keywords | Serotonin antagonists Hallucinogen Schizophrenia object-oriented programming 5-HT Receptor Pharmacology Depression economics Neurotransmitter |
| Key points | The 5-HT1BR, a nonhallucinogenic serotonin receptor, is implicated as a potential mediator of the behavioral and neural effects of psilocybin in mice. |
Abstract
should have read "Overall, our research implicates the 5-HT1BR, a nonhallucinogenic serotonin receptor, as a potential mediator of the behavioral and neural effects of psilocybin in mice."The final sentence of the Introduction should have read "Our findings suggest that the 5-HT1BR influences brain-wide neural changes following psilocybin administration and may contribute to its enduring antidepressant-like effects in mice."The first sentence of the second paragraph of the Discussion should have read "Though we find that 5-HT1BR contributes to the persisting effects of psilocybin, our data do not address its sufficiency.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |