Molecular Diagnostics, Circuit-Calming Modulators, and Controlled Neuroplastogens: Emerging Strategies in Precision Neuropsychiatric Therapeutics
Anna C. Renner, Robert B. Kargbo
ACS Medicinal Chemistry Letters December 16, 2025 DOI: 10.1021/acsmedchemlett.5c00716 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Scalability Computational biology Precision medicine Bioinformatics |
| Key findings | Three complementary inventions—a FOXG1-based blood diagnostic for PTSD, benzocyclobutenyl-methylamine modulators for neuronal hyperexcitability, and sublingual 5-MeO-DMT for nonhallucinogenic neuroplasticity—form a convergent framework for neuropsychiatric therapeutics. |
Abstract
New inventions introduce complementary advances across neuropsychiatric therapeutics: a blood-based gene-expression diagnostic centered on FOXG1 for objective PTSD detection; benzocyclobutenyl-methylamine modulators that normalize neuronal hyperexcitability; and templated-carrier sublingual 5-MeO-DMT formulations enabling controlled, nonhallucinogenic neuroplasticity. Together, these approaches form a convergent framework linking molecular diagnostics, targeted circuit modulation, and scalable affective therapeutics.
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