Endogenous N,N-Dimethyltryptamine and Sigma-1 Receptor Modulation as Enhancers of Neural-Substrate Coherence in the Swygert Theory of Everything AO (TSTOEAO)
Zenodo (CERN European Organization for Nuclear Research) November 25, 2025 DOI: 10.5281/zenodo.17711568 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | 5-MeO-DMT DMT |
| Keywords | Endogeny Modulation music Quantum Phase coherence Coupling piping Phase modulation Biophysics Coherence theory Biological system |
| Key points | Proposes that endogenous DMT, via sigma-1 receptor modulation, increases neural-substrate coherence, offering a unified mechanism for altered-state phenomena. |
Abstract
This paper presents the first quantitative model linking endogenous N,N-dimethyltryptamine (DMT) and sigma-1 receptor (Sig-1R) modulation to measurable increases in neural-substrate coherence (α) within the Swygert Theory of Everything AO (TSTOEAO). The framework integrates neuropharmacology, quantum biology, and substrate-coupling dynamics to show how Sig-1R chaperone activity stabilizes microtubule coherence and enhances phase alignment between neural oscillations and substrate eigenmodes. A full kinetic derivation, an IRB-ready experimental protocol (ZERO-DMT-01), and five specific falsifiable predictions are provided. The model is fully compatible with established biophysics and offers immediate experimental pathways using EEG, heartbeat-evoked potentials, and Ganzfeld-based forced-choice tasks. This work establishes DMT as a biologically regulated modulator of neural-substrate phase coupling and proposes a unified mechanism underlying a range of altered-state phenomena.