Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging
Noah Cavallaro, Priya Rai, David Akins, Sima Soltanpour, Md Taufiq Nasseef, Richard J. Ortiz, Dan Madularu, Praveen P Kulkarni, Craig F. Ferris
Neuropharmacology March 6, 2026 DOI: 10.1016/j.neuropharm.2026.110886 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Intervention | 5-MeO-DMT |
| Topics | 5-MeO-DMT DMT |
| Keywords | Wakefulness Brain mapping Anesthesia Functional connectivity Central nervous system Renin-angiotensin system studies |
| Citations | 1 |
| Key findings | The fMRI characterization of 5-MeO-DMT reveals a previously unreported sex difference in psychedelic response. |
Abstract
To our knowledge, this is the first fMRI characterization of 5-MeO-DMT in any species, and it reveals a previously unreported sex difference in psychedelic response. The rapid onset and brief duration of peak effects align with 5-MeO-DMT's unique pharmacological profile and clinical reports.