Psilocybin modulation of time-varying functional connectivity is associated with plasma psilocin and subjective effects
Anders Lykkebo-Valløe, Brice Ozenne, Sophia Armand, Morten Mørup, Melanie Ganz, Anders S. Olsen, M. Madsen, Dea Siggaard Stenbæk, Gitte M. Knudsen, Patrick M. Fisher
Neuroimage October 27, 2022 DOI: 10.1016/j.neuroimage.2022.119716 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preprint Peer reviewed |
|---|---|
| Intervention | Psilocybin |
| Topics | Psilocybin |
| Keywords | Modulation music Hallucinogen Functional connectivity |
| Citations | 44 |
| Key points | Psilocybin-induced acute perceptual psychedelic effects may stem from decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. |
Abstract
Our findings suggest that the acute perceptual psychedelic effects induced by psilocybin may stem from drug-level associated decreases in the occurrence and duration of lateral and medial frontoparietal connectivity motifs. We apply and argue for a modified approach to modeling eigenvectors produced by LEiDA that more fully acknowledges their underlying structure. Together these findings contribute to a more comprehensive neurobiological framework underlying acute effects of serotonergic psychedelics.
Citations in the library
Cited by 26
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- Navigating the chaos of psychedelic fMRI brain-entropy via multi-metric evaluations of acute psilocybin effects medRxiv July 3, 2023
- Shared functional connectome fingerprints following ritualistic ayahuasca intake. Neuroimage 2024
- Dynamic Functional Hyperconnectivity After Psilocybin Intake Is Primarily Associated With Oceanic Boundlessness. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging July 1, 2024
- Effect of a single psilocybin treatment on Fos protein expression in male rat brain. Neuroscience February 16, 2024
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Cites 32
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs Frontiers in Human Neuroscience 2014
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Proceedings of the National Academy of Sciences January 23, 2012
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