Structure-activity studies on hallucinogenic amphetamines using molecular connectivity
Lemont B. Kier, Lowell H. Hall
Journal of Medicinal Chemistry December 1, 1977 DOI: 10.1021/jm00222a019 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractA series of ring-substituted hallucinogenic amphetamines was analyzed using molecular connectivity, and a correlating equation was found between potency and connectivity terms. The equation allows interpretation of structure-activity relationships (SAR) and can predict potency for amphetamines not in the original list, as well as for mescalines and tryptamines.
Study at a glance
| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Keywords | Icon Computer science Citation database Information retrieval Library science |
| Citations | 64 |
| Key finding | A correlating equation between molecular connectivity and potency was found that can predict potency for hallucinogenic amphetamines, mescalines, and tryptamines. |
Abstract
A series of ring-substituted hallucinogenic amphetamines has been analyzed using molecular connectivity. A correlating equation has been found between potency and connectivity terms. The equation permits an interpretation of SAR. The equation is capable of predicting potency for amphetamines not in the list and mescalines and tryptamines.