Structure-activity studies on hallucinogenic amphetamines using molecular connectivity
Lemont B. Kier, Lowell H. Hall
Journal of Medicinal Chemistry December 1, 1977 DOI: 10.1021/jm00222a019 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Keywords | Icon Citation database Information retrieval Library science |
| Citations | 64 |
| Key points | A correlating equation between molecular connectivity and potency was found that can predict potency for hallucinogenic amphetamines, mescalines, and tryptamines. |
Abstract
A series of ring-substituted hallucinogenic amphetamines has been analyzed using molecular connectivity. A correlating equation has been found between potency and connectivity terms. The equation permits an interpretation of SAR. The equation is capable of predicting potency for amphetamines not in the list and mescalines and tryptamines.