Synthesis of a Tricyclic Mescaline Analogue by Catalytic C−H Bond Activation
Kateri A. Ahrendt, Robert G. Bergman, Jonathan A. Ellman
Organic Letters March 22, 2003 DOI: 10.1021/ol034228d (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Synthesis and biological evaluation Peer reviewed |
|---|---|
| Topics | Mescaline |
| Keywords | Yield engineering Tricyclic Olefin fiber Tandem Benzofuran Catalysis Stereochemistry Medicinal chemistry Combinatorial chemistry Organic chemistry |
| Citations | 99 |
| Key points | A tetrahydrobis(benzofuran) mescaline analogue was prepared in six steps and 38% overall yield via a tandem cyclization using directed C–H activation and olefin insertion. |
Abstract
[reaction: see text] A tetrahydrobis(benzofuran) mescaline analogue has been prepared in six steps and 38% overall yield from (4'-O-methyl)methyl gallate. The key step in this synthesis is a tandem cyclization reaction via directed C[bond]H activation followed by olefin insertion.
Citations in the library
Cited by 2
Cites 5
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