Is psilocybin an effective antidepressant and what is its Mechanism of action?
Cell Reports Medicine 2023 DOI: 10.1016/j.xcrm.2022.100906 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | People with medication-resistant depression |
| Intervention | Psilocybin |
| Dose | 25 mg |
| Duration | Short-term |
| Topics | Depression Psilocybin |
| Keywords | Psychedelics Mental health |
| Citations | 7 |
| Key findings | A single 25 mg dose of psilocybin has a short-term antidepressant effect in medication-resistant depression. |
Abstract
Goodwin et al.1 report a single 25 mg dose of psilocybin has an antidepressant effect short-term in medication-resistant depression. Unanswered questions include drug blood level as a guide to dose, psychedelic effects relationship to antidepressant benefit, and potential suicide risk of psilocybin.