Is psilocybin an effective antidepressant and what is its Mechanism of action?
Cell Reports Medicine January 1, 2023 DOI: 10.1016/j.xcrm.2022.100906 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractA single 25 mg dose of psilocybin produces a short-term antidepressant effect in people with medication-resistant depression. Unanswered questions remain about whether drug blood levels can guide dosing, how the psychedelic experience relates to the antidepressant benefit, and whether psilocybin carries a risk of suicide.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | People with medication-resistant depression |
| Intervention | Psilocybin |
| Dose | 25 mg |
| Duration | Short-term |
| Topics | Depression Psilocybin |
| Keywords | Psychedelics Mental health |
| Citations | 7 |
| Key finding | A single 25 mg dose of psilocybin has a short-term antidepressant effect in medication-resistant depression. |
Abstract
Goodwin et al.1 report a single 25 mg dose of psilocybin has an antidepressant effect short-term in medication-resistant depression. Unanswered questions include drug blood level as a guide to dose, psychedelic effects relationship to antidepressant benefit, and potential suicide risk of psilocybin.