Role of the endocannabinoid system in MDMA intracerebral self‐administration in rats
Daniela Braida, Mariaelvina Sala
British Journal of Pharmacology August 1, 2002 DOI: 10.1038/sj.bjp.0704825 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA CP 55 940 SR 141716A |
| Dose | MDMA 0.01–2 μg per infusion; CP 55,940 0.4 μg per infusion; SR 141716A 0.5 mg kg⁻¹ i.p. |
| Topics | MDMA |
| Keywords | Self-administration Pharmacology Anesthesia |
| Citations | 64 |
| Key findings | MDMA self-administration in rats is modulated by the endocannabinoid system, as a cannabinoid agonist reduces and a CB1 antagonist increases MDMA intake. |
Abstract
I.c.v. self‐administration of MDMA (0.01–2 μg per infusion), alone and in combination with CP 55,940 (0.4 μg infusion −1 ), was studied on an operant responding procedure. On the basis of individual preference for one of two levers, developed during training, rats were allowed to self‐administer vehicle from the preferred lever and MDMA from the other. Pressings on the MDMA associated‐lever, except for the maximal unit dose, progressively increased. The combination of CP 55,940 with MDMA (1 μg infusion −1 ) reduced the number of drug‐associated lever pressings compared to the single drugs. Pre‐treatment with SR 141716A (0.5 mg kg −1 i.p.), 15 min before each daily session, significantly increased MDMA self‐administration. These findings suggest that MDMA self‐administration is under endogenous tonic control by the endocannabinoid system. British Journal of Pharmacology (2002) 136 , 1089–1092. doi: 10.1038/sj.bjp.0704825
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 15
- MDMA self‐administration in rats: acquisition, progressive ratio responding and serotonin transporter binding European Journal of Neuroscience November 16, 2007
- Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward. Biological Psychiatry February 1, 2008
- MDMA Self-Administration in Laboratory Animals: A Summary of the Literature and Proposal for Future Research Neuropsychobiology 2009
- Effect of the CB1 cannabinoid agonist WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference in mice Behavioral and Brain Functions March 22, 2010
- MDMA & Cannabis: A Mini-Review of Cognitive, Behavioral, and Neurobiological Effects of Co-Consumption Current Drug Abuse Reviews June 1, 2011
and 10 more in the library
Cites 3
- Marijuana and cannabinoid regulation of brain reward circuits. British Journal of Pharmacology September 2004
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- Self-injection of d,1-3,4-methylenedioxymethamphetamine (MDMA) in the baboon. Psychopharmacology 1987