Defining 5-MeO-DMT in Historical and Cultural Contexts
Azul Delgrasso
World Futures February 17, 2024 DOI: 10.1080/02604027.2024.2330255 (opens in new tab)
Study at a glance
AI-extracted from the abstractAbstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic and entheogenic compound that has been used for centuries by Indigenous Peoples in the Amazon, Caribbean, and more recently in communities in Northern Mexico in ceremonial practices and to connect with nature. In recent years, there has been growing interest in 5-MeO-DMT to treat mental health conditions such as depression, anxiety and post-traumatic stress disorder (PTSD). In response, there has been an increase in scientific research of the efficacy of 5-MeO-DMT in treating such conditions. Little is known about the compound's historical use; this paper will explore and examine the known writings about the origins and original use of 5-MeO-DMT. Additionally, this paper will present the limited data and accounts regarding the use of 5-MeO-DMT and the intersection of those accounts in historical and cultural contexts.
Comparable studies
Other theoretical and historical papers on 5-MeO-DMT, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor | 2009 | Theoretical or philosophical paper | |
| Analytical chemistry of synthetic routes to psychoactive tryptamines : Part I. Characterisation of the Speeter and Anthony synthetic route to 5-methoxy-N,N-diisopropyltryptamine using ESI-MS-MS and ESI-TOF-MS | 2004 | Theoretical or philosophical paper | |
| Enlightening the "Spirit Molecule": Photomodulation of the 5-HT2A Receptor by a Light-Controllable N,N-Dimethyltryptamine Derivative. | 2022 | Theoretical or philosophical paper | |
| Conformational, spectroscopic and nonlinear optical properties of biologically active N,N-dimethyltryptamine molecule: a theoretical study. | 2014 | Theoretical or computational study | |
| Simple syntheses of lespedamine and 5-bromo-n,n-dimethyltryptamine based on 1-hydroxyindole chemistry | 1995 | Theoretical or philosophical paper |
Citations in the library
Cited by 5
- Preclinical Comparison of DMT and 5-MeO-DMT Reveals Behavioral Dissociation, Distinct TrkB Activation and Differential Plasticity Profiles bioRxiv (Cold Spring Harbor Laboratory) August 12, 2026
- Attunement as Leadership: Council Practice and Low-Dose 5-MeO-DMT as Transdisciplinary Pathways to Transformative Leadership World Futures April 29, 2026
- Treatment of major depressive disorder and treatment resistant depression with 5-MeO-DMT: Impact of 25 years of non-traditional public scientific communication and education on clinical development and commercialization Psychedelics April 25, 2026
- Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis Journal of Psychopharmacology April 12, 2026
- Fabricated Ancestrality: The Sonoran Desert Toad, Psychedelic Globalization, and the Ecological Politics of 5-MeO-DMT Psychedelics March 1, 2026
Cites 17
- The hallucinogenic world of tryptamines: an updated review. Archives of Toxicology August 1, 2015
- A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology April 13, 2019
- N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function Frontiers in Neuroscience August 6, 2018
- The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption. Journal of Psychopharmacology July 1, 2018
- Bufo alvarius: a potent hallucinogen of animal origin. Journal of Ethnopharmacology 1994
and 12 more in the library