Platelet serotonin uptake sites increased in drinkers ofayahuasca
James C. Callaway, Mauno M. Airaksinen, Dennis J. Mckenna, Glacus S. Brito, Charles S. Grob
Psychopharmacology November 1, 1994 DOI: 10.1007/bf02245347 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Healthy male drinkers of ayahuasca and healthy male controls |
| Intervention | Ayahuasca |
| Topics | Ayahuasca Serotonin |
| Keywords | Citalopram Serotonin transporter Platelet Extracellular Dissociation constant Endocrinology Reuptake inhibitor Pharmacology |
| Citations | 79 |
| Key findings | Ayahuasca drinkers had an increased number of platelet serotonin transporter binding sites compared to controls, with no change in dissociation constant. |
Abstract
The binding of [3H]citalopram to the platelet 5-hydroxytryptamine (5-HT) transporter was measured in a group of healthy male drinkers of ayahuasca, a psychoactive sacrament indigenous to Amazonia, and a group healthy male controls. An increased number of binding sites (Bmax) in the platelets of ayahuasca drinkers was found, while the dissociation constant (Kd) remained the same for both groups. If indicative of neuronal 5-HT uptake activity, these results would suggest a decreased concentration of extracellular 5-HT, or a response to increased production and release of 5-HT. Such changes in 5-HT synaptic activity, in this case, should not be misinterpreted as an indication of developing neurological or psychiatric illness.
Comparable studies
Other observational and cohort studies on ayahuasca, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report Patients with a depressive disorder | 2015 | Observational study | |
| The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network Experienced subjects | 2015 | Observational cohort | n = 10 |
| Human Psychopharmacology of Hoasca, A Plant Hallucinogen Used in Ritual Context in Brazil Long-term members of a syncretic church that uses hoasca as a psychoactive sacrament... | 1996 | Observational cohort with matched controls | n = 30 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Personality, Psychopathology, Life Attitudes and Neuropsychological Performance among Ritual Users of Ayahuasca: A Longitudinal Study Regular ayahuasca users and active controls in non-ayahuasca religions | 2012 | Observational cohort | n = 242 |
Citations in the library
Cited by 51
- Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers Psychopharmacology February 22, 2001
- Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges. Pharmacology & Therapeutics May 1, 2004
- Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant Psychopharmacology March 30, 2006
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members Journal of Ethnopharmacology April 26, 2007
and 46 more in the library