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Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice

Yasmim A. Serra, Thaísa Barros-Santos, Alexia Anjos-Santos, Natali D. Kisaki, Caio Jovita-Farias, João Pereira Leite, Maria Clara E. Santana, João P. S. A. Coimbra, Nailton M. S. de Jesus, Agnieszka Sulima, Paulo César Ribeiro Barbosa, Elena L. A. Malpezzi-Marinho, Kenner C Rice, Alexandre J. Oliveira-Lima, Laís F. Berro, Eduardo A V Marinho

Psychopharmacology March 7, 2022 DOI: 10.1007/s00213-022-06104-w (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Population Mice
Intervention Ayahuasca
Topics Ayahuasca Serotonin
Keywords Self-administration Pharmacology Receptor Hallucinogen
Citations 28
Key findings Ayahuasca treatment during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects.

Abstract

Treatment with ayahuasca during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects to emerge. Our findings support a potential for ayahuasca and other 5-HT2A receptor agonists as adjunctive pharmacotherapies for the treatment of AUD.

Comparable studies

Other preclinical and animal studies on ayahuasca, most cited first.

Study Year Design Participants
Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of Ayahuasca Eight ayahuasca samples from Peru and several Banisteriopsis caapi cultivars 1984 Qualitative and quantitative chemical analysis with in vitro assay
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro Progenitor cells from subventricular and subgranular zones of adult mice brains 2017 In vitro experimental study
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo Mice 2020 In vitro and in vivo experimental study
Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat Female Wistar rats 2015 Observational cohort
Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice Mice 2015 Experimental study

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Ayahuasca Serotonin Addiction