Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice
Yasmim A. Serra, Thaísa Barros-Santos, Alexia Anjos-Santos, Natali D. Kisaki, Caio Jovita-Farias, João Pereira Leite, Maria Clara E. Santana, João P. S. A. Coimbra, Nailton M. S. de Jesus, Agnieszka Sulima, Paulo César Ribeiro Barbosa, Elena L. A. Malpezzi-Marinho, Kenner C Rice, Alexandre J. Oliveira-Lima, Laís F. Berro, Eduardo A V Marinho
Psychopharmacology March 7, 2022 DOI: 10.1007/s00213-022-06104-w (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Intervention | Ayahuasca |
| Topics | Ayahuasca Serotonin |
| Keywords | Self-administration Pharmacology Receptor Hallucinogen |
| Citations | 28 |
| Key findings | Ayahuasca treatment during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects. |
Abstract
Treatment with ayahuasca during alcohol abstinence blocked the expression of alcohol self-administration in mice, and 5-HT2A receptor activation is critical for those effects to emerge. Our findings support a potential for ayahuasca and other 5-HT2A receptor agonists as adjunctive pharmacotherapies for the treatment of AUD.