Identification of N,N‐dimethyltryptamine and β‐carbolines in psychotropic ayahuasca beverage
Cristiana Gambelunghe, Kyriaki Aroni, Riccardo Rossi, L. D. Moretti, Mauro Bacci
Biomedical Chromatography May 27, 2008 DOI: 10.1002/bmc.1023 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Chemical analysis Peer reviewed |
|---|---|
| Topics | Ayahuasca 5-MeO-DMT DMT |
| Keywords | Harmine Harmaline Traditional medicine Hallucinogen Chromatography Pharmacology Ecology Alkaloids |
| Citations | 52 |
| Key points | The seized liquid contained N,N-dimethyltryptamine, harmine, and harmaline, identifying it as Ayahuasca. |
Abstract
Abstract Recently many people have shown great interest in traditional indigenous practices and popular medicine, involving the ingestion of natural psychotropic drugs. We received a request to analyze and determine the nature of a dark green liquid with a dark brown plant sediment, which the police had seized at an airport and inside the home of a person belonging to the ‘Santo Daime’ religious movement. Gas chromatography/mass spectrometry analysis of the extract identified N , N ‐dimethyltryptamine, a potent hallucinogen, and the β ‐carboline alkaloids harmine and harmaline, revealing monoamine oxidase A‐inhibiting properties. These substances are typical components of Ayahuasca, a South American psychotropic beverage obtained by boiling the bark of the liana Banisteriopsis caapi together with the leaves of various admixture plants, principally Psychotria viridis . Copyright © 2008 John Wiley & Sons, Ltd.
Citations in the library
Cited by 27
- Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms Pharmacological Reviews December 16, 2020
- Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Current Drug Metabolism October 1, 2010
- When the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor Science Signaling March 10, 2009
- Direct analysis of psychoactive tryptamine and harmala alkaloids in the Amazonian botanical medicine ayahuasca by liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of Chromatography A December 18, 2009
- Ayahuasca: Uses, Phytochemical and Biological Activities Natural Products and Bioprospecting May 27, 2019
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Cites 11
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics Journal of Pharmacology and Experimental Therapeutics June 18, 2003
- Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers Psychopharmacology February 22, 2001
- Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges. Pharmacology & Therapeutics May 1, 2004
- Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant Psychopharmacology March 30, 2006
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