Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review
Aryan Sarparast, Kelan Thomas, Benjamin Malcolm, Christopher S. Stauffer
Psychopharmacology March 7, 2022 DOI: 10.1007/s00213-022-06083-y (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Topics | MDMA Psilocybin |
| Keywords | Hallucinogen Psychoactive drug Pharmacology |
| Citations | 85 |
| Key findings | Psychiatric drugs, particularly serotonergic medications like SSRIs, can alter the effects and safety profile of MDMA and psilocybin, necessitating careful management during psychedelic-assisted therapy. |
Abstract
As MDMA and psilocybin continue to move through the FDA drug development process, this systematic review offers a compilation of existing research on psychiatric drug-drug interactions with MDMA or psilocybin.
Comparable studies
Other systematic reviews and meta-analyses on MDMA, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A review of the acute subjective effects of MDMA/ecstasy | 2006 | Systematic review | |
| Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review Patients in clinical trials with MDMA or serotonergic psychedelics | 2022 | Systematic review | n = 598 |
| Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A preliminary meta-analysis and comparison to prolonged exposure therapy Patients with PTSD | 2016 | Meta-analysis | |
| The neuropsychology of ecstasy (MDMA) use: a quantitative review MDMA users | 2007 | Meta-analysis | |
| Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: A systematic review and meta-analysis. Individuals with chronic, treatment-refractory PTSD | 2020 | Systematic review and meta-analysis | n = 106 |
Citations in the library
Cited by 71
- Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey Frontiers in Psychiatry September 19, 2023
- Attenuation of psilocybin mushroom effects during and after SSRI/SNRI antidepressant use Journal of Psychopharmacology June 8, 2023
- Cardiovascular safety of psychedelic medicine: current status and future directions Pharmacological Reports October 24, 2023
- Drug–drug interactions involving classic psychedelics: A systematic review Journal of Psychopharmacology November 20, 2023
- Neuroimaging in psychedelic drug development: past, present, and future. Molecular Psychiatry September 1, 2023
and 66 more in the library
Cites 95
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs Frontiers in Human Neuroscience 2014
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
and 90 more in the library