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Chronic Ketamine Toxicity Involving both Urinary and Hepatobiliary Systems.

Alexander Cotza, Liesbeth Meylaerts

Journal of the Belgian Society of Radiology 2026 DOI: 10.5334/jbsr.4197 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report Peer reviewed
Sample size 1
Population Young adult with chronic ketamine abuse
Topics Esketamine Ketamine
Keywords Ketamine abuse Ketamine toxicity Ketamine-induced cholangiopathy Ketamine-induced uropathy
Key findings Ketamine toxicity can cause concurrent uropathy and cholangiopathy, indicating it is a multisystem disorder.

Abstract

Chronic ketamine abuse is a well-recognized cause of lower urinary tract injury. Hepatobiliary manifestations are less frequently reported. A case is presented of concomitant ketamine-induced uropathy and cholangiopathy in a young adult. This underscores the importance of considering ketamine toxicity as a multisystem disorder. Teaching point: Beyond the well-recognized urinary tract involvement, radiologists attention is drawn to hepatobiliary manifestations of chronic ketamine toxicity.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study Year Design Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units 2008 Retrospective case series n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients 1998 Case series n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants 2009 Case series n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4

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Esketamine Ketamine