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Atypical Manifestation of Postoperative Delirium After an Opioid-free Prostatectomy: A Case Study Report.

Karina Bridges, Ionela Morosanu, Lilian Njoki, Nilka Schulman

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses January 28, 2026 DOI: 10.1016/j.jopan.2025.11.008 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Case report Peer reviewed
Sample size 1
Population Patient undergoing robotic-assisted prostatectomy
Interventions Ketamine Lidocaine Magnesium
Topics Ketamine
Keywords Case reports Opioid-free anesthesia Patient safety Postoperative complications Postoperative delirium
Key findings Postoperative delirium can occur in the context of an opioid-free anesthesia protocol using ketamine, lidocaine, and magnesium.

Abstract

At a clinical research hospital, the Department of Perioperative Services has recently implemented an opioid-free anesthesia protocol for selected patients undergoing robotic-assisted prostatectomy. This protocol incorporates intraoperative infusions of ketamine, lidocaine, and magnesium as part of a multimodal analgesic strategy. The present case report describes an unusual occurrence of postoperative delirium in this context and aims to provide educational insights into its clinical presentation, contributing factors, and management.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study Year Design Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units 2008 Retrospective case series n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients 1998 Case series n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants 2009 Case series n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4

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