Brief report: Ketamine-assisted "bridge therapy" for opioid tapering in complex cases.
Mariana C De Oliveira, Cláudia C De Araujo Palmeira, André B Negrão, Ziyad A Hadi, Julia R Arana, Rita De Cássia Ferreira Duarte, Joice L P Da Silva, Gustavo K Matsui, João F D Rapozero, Douglas H Crispim, André Malbergier, João M Castaldelli-Maia
American Journal on Addictions January 28, 2026 DOI: 10.1111/ajad.70131 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 25-year-old woman with opioid use disorder, chronic pain, and major depressive disorder |
| Intervention | Intravenous ketamine infusions |
| Dose | 0.5 mg/kg weekly |
| Duration | 8-week protocol |
| Topics | Esketamine Ketamine |
| Citations | 1 |
| Key findings | Ketamine-assisted bridge therapy enabled a 50% reduction in methadone dosage with improvements in pain, cravings, withdrawal symptoms, and psychotherapy engagement. |
Abstract
Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25-year-old woman with OUD, chronic pain, and major depressive disorder underwent an 8-week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering. Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement. Ketamine-assisted "bridge therapy" treatment may support opioid tapering in complex cases. This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.
Comparable studies
Other case reports and case series on ketamine, most cited first.
Citations in the library
Cites 4
- A Phase 2 Open Label Study of Efficacy, Safety, and Tolerability of SLS-002 (Intranasal Racemic Ketamine) in Adults with MDD at Imminent Risk of Suicide. Psychopharmacology Bulletin March 4, 2024
- Single Versus Repeated Sessions of Ketamine-Assisted Psychotherapy for People with Heroin Dependence Journal of Psychoactive Drugs March 1, 2007
- Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial British medical journal February 2, 2022
- Ketamine in treating opioid use disorder and opioid withdrawal: a scoping review. Frontiers in Psychiatry 2025