Clinical analysis of dexmedetomidine-esketamine combined with intranasal administration before laparoscopic high ligation of hernia sac in infants and young children.
Cuicui Shi, Chuanyue Zong, Jia Yang, Hao Zhang, Can Qi, Mao Li
African health sciences March 1, 2025 DOI: 10.4314/ahs.v25i1.44 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 90 |
| Population | Children aged 8–14 years undergoing laparoscopic high ligation of hernia sacs |
| Interventions | Dexmedetomidine Esketamine |
| Topics | Esketamine |
| Keywords | Dexmedetomidine Intranasal sedation |
| Key findings | Intranasal dexmedetomidine combined with esketamine provided faster onset and longer sedation than midazolam, with higher Ramsay scores and no harm to cognitive function. |
Abstract
Studying To investigate the clinical values of dexmedetomidine and esketamine combined with intranasal infusion before laparoscopic high ligation of hernia sacs in infants and young children. In our hospital, 90Ninety children aged 8-14 years underwent surgical high ligation of the hernia sac between March 2021 and March 2022 were included. During March 2021 to March 2022, 90 children aged 8-14 underwent surgical high ligation of hernia sacs at our hospital. The study and control groups were divided. Each group had 45 cases. A routine fast was given to all the children before anesthesia, and they received midazolam for the contrast set and dexmedetomidine combined with esketamine for the examination set. The onset time, recovery time, sedation time and other indicators were analyzed. The onset time of sedation in the study group was significantly lower than that in the control group, and the sedation time was significantly higher than that in the control group (P<0.05). The Ramsay score of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After sedation, the Montreal cognitive assessment (MoCA) scores of the study group was significantly lower than the control group (P<0.05). After sedation, the Ramsay score and MoCA score were significantly positively correlated (P<0.05). The use of Dexmedetomidine combined with esketamine nasal drops in infants and young children undergoing laparoscopic high ligation of hernia sac is an effective and safe sedation technique. It not only improves sedation but also reduces the incidence of adverse reactions. Furthermore, it does not impair the cognitive function of children. The combination of dexmedetomidine with esketamine intranasal instillation can improve sedation, reduce adverse reactions, and will not harm them. Clinical efficacy, safety, and cognitive function are high in children.
Comparable studies
Other randomized controlled trials on esketamine, most cited first.