Neuroimaging of Serotonergic and Psychedelic Agonist Drug Challenges in Non-Human Primates
Ande Bagdasarian, Kristian Larsen, Patrick M. Fisher, Hanne D. Hansen, Hsiao‐ying Wey
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition November 26, 2024 DOI: 10.58530/2024/1133 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Non-human primates |
| Interventions | Psilocybin Lisuride 25CN-NBOH |
| Topics | Serotonin |
| Keywords | Agonist Neuroimaging |
| Key findings | Psilocybin and lisuride induce bi-phasic hemodynamic responses, while 25CN-NBOH produces a monophasic response; bi-phasic patterns may reflect non-selective drug targeting. |
Abstract
Motivation: Acute effects of psychedelic drugs are under-reported in neuroimaging studies, warranting further investigation of their immediate pharmacology to explore the potential to monitor treatment response with imaging. Goal(s): Our goal was to assess acute impacts of serotonergic (psychedelic and non-psychedelic) agonists on hemodynamics in non-human primates (NHP). Approach: Pharmacological-MRI (phMRI) was used to measure cerebral blood volume (CBV) changes by psilocybin, lisuride and 25CN-NBOH. Results: Psilocybin and lisuride induced bi-phasic hemodynamic response, whereas 25CN-NBOH was monophasic. Bi-phasic phenomena may be due to non-selectivity of agonist drugs. Elevated CBV at higher psilocybin doses persists longitudinally, while lisuride and 25CN-NBOH modulations trend toward baseline. Impact: Bi-phasic signal profiles and downstream impacts to cerebral hemodynamics may reflect non-selective targeting of psilocybin and lisuride, highlighting the sensitivity of phMRI in drug evaluation.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |