Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics
Dino Luethi, Matthias E. Liechti
The International Journal of Neuropsychopharmacology May 24, 2018 DOI: 10.1093/ijnp/pyy047 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | Pharmacology Monoamine neurotransmitter Dopamine transporter Serotonin transporter Potency Norepinephrine transporter In vitro Intrinsic activity Receptor |
| Key findings | Rapid assessment of in vitro pharmacological profiles of new psychoactive substances can help predict psychoactive doses and effects in humans and facilitate appropriate scheduling. |
Abstract
The rapid assessment of in vitro pharmacological profiles of new psychoactive substances can help to predict psychoactive doses and effects in humans and facilitate the appropriate scheduling of new psychoactive substances.
Comparable studies
Other narrative reviews on serotonin, most cited first.
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- Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice ACS Pharmacology & Translational Science November 2, 2022
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Cites 24
- Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Synapse 2000
- Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sciences December 17, 1984
- Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. European Neuropsychopharmacology May 20, 2016
- Prediction of Psilocybin Response in Healthy Volunteers PLoS One February 17, 2012
- Modern Clinical Research on LSD Neuropsychopharmacology April 27, 2017
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