Neuroscience: Special K gets an 'A'.
Jovin R Jacobs, Adam D Douglass
Current biology : CB April 21, 2025 DOI: 10.1016/j.cub.2025.03.006 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Zebrafish |
| Intervention | Ketamine |
| Keywords | Mental health Antidepressants Behavioral research Pharmacology |
| Key points | Ketamine promotes long-term improvements in behavioral persistence in a zebrafish model of depression through a novel mechanism. |
Abstract
A hallmark of depression is a tendency to become passive when faced with overwhelming challenges. A recent study models this phenomenon in zebrafish and discovers a novel mechanism by which the antidepressant drug ketamine promotes long-term improvements in behavioral persistence.