Visualizing drug actions on dendrites: psilocybin and other classic psychedelics
Ling-Xiao Shao, Clara Liao, Ian Gregg, Pasha A. Davoudian, Neil K. Savalia, Kristina Delagarza, Alex C. Kwan
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study |
|---|---|
| Population | Mice |
| Interventions | Psilocybin other psychoactive drugs |
| Topics | Psilocybin |
| Keywords | Hallucinogen Cortex anatomy Frontal cortex Neuron |
| Key findings | Psilocybin administration alters dendritic spines in the mouse frontal cortex, with effects distinct from other psychoactive drugs. |
Abstract
To determine effects of psychedelics on neuronal architecture, we used two-photon microscopy to image dendritic spines in mouse frontal cortex after administering psilocybin (Neuron, 109, 2535, 2021) and compared with other psychoactive drugs.