Psilocybin‐assisted therapy leads to personality shifts in patients with alcohol use disorder
The Brown University Psychopharmacology Update March 27, 2025 DOI: 10.1002/pu.31300 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Secondary analysis of a randomized trial Peer reviewed |
|---|---|
| Population | Adults with alcohol use disorder |
| Topics | Addiction Psilocybin |
| Keywords | Psychotherapist Hallucinogen |
| Key findings | Psilocybin-assisted therapy was associated with personality shifts toward normalization of abnormal trait expression, and decreased impulsiveness was linked to reduced drinking post-treatment, especially among those with moderate- or high-risk drinking before treatment. |
Abstract
Adults with alcohol use disorder who received two sessions of psilocybin‐assisted therapy demonstrated personality shifts toward normalization of abnormal trait expression, a secondary analysis of a randomized trial has found. A decrease in impulsiveness was found to be associated with reduced drinking post‐treatment, with the strongest effect for psilocybin‐treated individuals who had engaged in moderate‐ or high‐risk drinking before treatment.
Comparable studies
Other randomized controlled trials on psilocybin for addiction, most cited first.