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Legal and Regulatory Barriers to Medical Psilocybin Use: An International Overview

Mohamad Chweikh

October 2, 2025 preprint DOI: 10.31219/osf.io/dy5cu_v1 (opens in new tab) via OpenAlex

Study at a glance

AI-extracted from the abstract
Characteristics Review
Topics Psilocybin
Key findings The legal status of psilocybin varies significantly across countries, creating barriers for clinical use and research.

Abstract

Psilocybin has emerged as a promising therapeutic agent for psychiatric and neurological disorders. However, its legal status varies significantly across countries, creating barriers for clinical use and research. This paper provides an international overview of the regulatory landscape governing medical psilocybin, highlighting key legal restrictions, policy challenges, and emerging frameworks that support clinical trials and compassionate use. Understanding these barriers is crucial for clinicians, researchers, and policymakers.

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