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Depression: Psilocybin etwas besser als Escitalopram

Zeitschrift für Phytotherapie August 1, 2022 DOI: 10.1055/a-1857-9047 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Randomized controlled trial Peer reviewed
Sample size	59
Population	Adults with moderate-to-severe major depressive disorder
Interventions	Psilocybin Escitalopram
Duration	6-week intervention
Topics	Anxiety Psilocybin Depression
Keywords	Escitalopram Psychoanalysis Hallucinogen Antidepressant
Key findings	Psilocybin therapy was associated with greater reductions in depressive symptoms than escitalopram at 6 weeks, as measured by the QIDS-SR-16.

Abstract

Carhart-Harris R, Giribaldi B, Nutt DJ et al. Trial of psilocybin versus escitalopram for depression. N Engl J Med 2021; 384: 1402–1411. doi:10.1056/ NEJMoa2032994

Comparable studies

Other randomized controlled trials on psilocybin for anxiety, most cited first.

Study	Year	Design	Participants
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety	2016	Randomized controlled trial	n = 51
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Patients with cancer-related anxiety and depression	2016	Double-blind, placebo-controlled, crossover trial	n = 29
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Hallucinogen-naïve adults reporting regular participation in religious or spiritual...	2006	Double-blind study	n = 36
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Adults with advanced-stage cancer and anxiety	2010	Double-blind, placebo-controlled study	n = 12
Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies Healthy human subjects	2010	Pooled analysis of double-blind placebo-controlled experimental studies	n = 110

Explore topics

Anxiety Psilocybin Depression

By condition and practice

Psilocybin for anxiety Psilocybin for depression