Psilocybin use in bipolar disorder: A comprehensive review
André Do, Laurence Cloutier, Lydia Hébert‐tremblay, Christel Thauvin
Journal of Affective Disorders October 31, 2025 DOI: 10.1016/j.jad.2025.120485 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Depression economics Hallucinogen Bipolar disorder Bipolar illness Value mathematics Medline Psychotherapist |
| Citations | 1 |
| Key findings | The efficacy and safety of psilocybin for bipolar depression remain unclear, and more research is needed to clarify its therapeutic value. |
Abstract
Despite its promising potential, the efficacy and safety of psilocybin in the treatment of BD depression remain unclear, and future research is essential to clarify its therapeutic value in BD.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cites 27
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression. New England Journal of Medicine November 3, 2022
- Single-Dose Psilocybin Treatment for Major Depressive Disorder JAMA August 31, 2023
- Increased global integration in the brain after psilocybin therapy for depression. Nature Medicine April 11, 2022
and 22 more in the library