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Active Constituents of Psilocybin Mushroom Edibles

Richard B. van Breemen, Daniel Simchuk, Bjorn Fritzsche, Daniel Huson, Scott Kuzdzal, Jonathan Ferguson

JAMA Network Open September 11, 2025 DOI: 10.1001/jamanetworkopen.2025.31345 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Case series Case report Peer reviewed
Population Unregulated psilocybin mushroom edibles
Topics Psilocybin
Citations 1
Key findings Unregulated psilocybin mushroom edibles contain multiple active alkaloids with inconsistent concentrations and labeling.

Abstract

This case series evaluates the active constituents of unregulated psilocybin mushroom edibles.

Comparable studies

Other case reports and case series on psilocybin, most cited first.

Study Year Design Participants
Psilocybin Mushroom (Psilocybe semilanceata) Intoxication with Myocardial Infarction 18-year-old man 1998 Case study n = 1
Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF) Person with leg amputation and phantom-limb pain 2018 Case study n = 1
Hallucinogen persisting perception disorder after psilocybin consumption: a case study 18-year-old man with HPPD after mixed psilocybin and cannabis intoxication 2005 Case study n = 1
Microdosing psilocybin for chronic pain: a case series Individuals with chronic neuropathic pain 2022 Case series n = 3
Psilocybin and Obsessive Compulsive Disorder Individual with Obsessive Compulsive Disorder 2014 Case study n = 1

Citations in the library

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