Neural correlates of the personality factor openness before and after psilocybin-therapy to depressed patients
Manca Peskar
Zenodo (CERN European Organization for Nuclear Research) August 31, 2019 preprint DOI: 10.5281/zenodo.7796283 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort |
|---|---|
| Population | Individuals with treatment-resistant depression |
| Intervention | Psilocybin-assisted intervention |
| Topics | Psilocybin |
| Keywords | Openness to experience Clinical psychology Psychotherapist Personality |
| Key findings | Changes in openness to experience are associated with neural correlates that may mediate clinical improvements following psilocybin-assisted therapy. |
Abstract
This document is my Master's Thesis for the Research Master Cognitive Neuroscience program at Maastricht University. The present study investigated the relationship between openness and its neural correlates in treatment-resistant depression preceding and following a psilocybin-assisted intervention, to (i) extent the findings of personality neuroscience from healthy to depressed population and (ii) unfold the neural mechanisms that could be mediating clinical improvements.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |