The Occurrence of Tryptamine Derivatives in Psilocybe semilanceata
Rudolf Brenneisen, Stefan Borner
Zeitschrift für Naturforschung C August 1, 1988 DOI: 10.1515/znc-1988-7-806 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 52 |
| Population | Psilocybe semilanceata mushroom samples from Switzerland |
| Duration | 1-5 year collection period |
| Topics | Psilocybin |
| Keywords | Tryptamine Hallucinogen Mushroom Alkaloid Chromatography |
| Citations | 10 |
| Key findings | Psilocybin and baeocystin levels in Psilocybe semilanceata vary widely depending on origin, year, size, and mushroom part, with psilocin present only in traces. |
Abstract
The content of tryptamine derivatives in Psilocybe semilanceata, a popular hallucinogenic mushroom, was measured by high-performance liquid chromatography. Most of the 52 samples have been collected at several localities in Switzerland during a 1-5 year period. The content of psilocybin and baeocystin varied in the range of 0.21-2.02% and 0.05-0.77%, respectively, whereas only traces of psilocin were present. The variability of the alkaloid level depending on origin, year of collection, size and part of mushrooms is discussed.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |
Citations in the library
Cited by 6
- Discovery of a new caerulescent Psilocybe mushroom in Germany: Psilocybe germanica sp.nov. Drug Testing and Analysis March 31, 2015
- Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis. Fungal biology and biotechnology April 25, 2024
- Chemical Composition and Biological Activities of Psilocybe Mushrooms: Gaps and Perspectives Pharmaceuticals July 1, 2025
- Chemical Constituents of Psilocybe Sensu Stricto Mushrooms. A 1958 – 2025 Comprehensive Review Journal of the Mexican Chemical Society July 7, 2026
- Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit–Risk Considerations in Policy and Clinical Development Biomolecules July 3, 2026
and 1 more in the library