Phytochemical screening, phenolic and flavonoid contents, psilocybin, antioxidant, and acetylcholinesterase inhibition activities of the aqueous extract from the fungi Cyathus striatus, Laternea dringii, and Marasmius haematocephalus
D Silva, Antônio Carlos Pereira de Menezes Filho, Aurélio Ferreira Melo, Porshia Sharma, Tullyo Henrique Lima Machado, Vanêcia Oliveira Cunha Machado, Matheus Vinícius Abadia Ventura
Brazilian Journal of Science November 1, 2024 DOI: 10.14295/bjs.v3i11.694 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Aqueous extracts of Cyathus striatus, Laternea dringii, and Marasmius haematocephalus mushrooms |
| Topics | Psilocybin |
| Keywords | Phytochemical Flavonoid Traditional medicine Antioxidant |
| Citations | 3 |
| Key findings | Aqueous extracts of Cyathus striatus, Laternea dringii, and Marasmius haematocephalus contain phytochemicals including flavonoids and phenolics, show antioxidant activity, and inhibit acetylcholinesterase, with M. haematocephalus showing the strongest inhibition at 77.14%. |
Abstract
Various families of mushrooms contain important phytochemicals with significant potential. This study aimed to investigate the phytochemical prospecting, presence of psilocybin, antioxidant activities, and acetylcholinesterase inhibition in aqueous extracts of Cyathus striatus, Laternea dringii, and Marasmius haematocephalus. Aqueous extracts were produced from mushrooms, and phytochemical groups were determined. The total phenolic and flavonoid content, DPPH reduction capacity, and FRAP were quantitatively determined. The acetylcholinesterase inhibition assay was performed, and the results were expressed as AChE inhibition percentages. Phytochemical groups such as flavonoids, phenolics, alkaloids, organic acids, and aliphatic compounds were positively detected. For phenolics, the extracts showed values of 208.44, 134.11, and 100.09 mg GAE g TPC-1; for flavonoids, values of 45.12, 56.06, and 39.71 mg QE g TFC-1. The FRAP reduction capacity showed values of 7.56, 14.43, and 4.15 µM TE g-1, while for DPPH, the values were 100.07, 88.12, and 133.65 µg mL-1. Low, medium, and strong AChE inhibition activity was observed with values of 43.11%, 68.53%, and 77.14%, respectively, for C. striatus, L. dringii, and M. haematocephalus. The aqueous extracts of Cyathus striatus, Laternea dringii, and Marasmius haematocephalus exhibited various phytomolecules groups with potential biological activities observed in this study.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |