Psilocybin-induced Autonomic, Perceptual, and Behavioral Change
Pharmacopsychiatry November 1, 1968 DOI: 10.1055/s-0028-1094227 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 15 |
| Population | College-educated male and female volunteers |
| Intervention | Psilocybin |
| Dose | 160 µg/kg |
| Topics | Psilocybin |
| Keywords | Perception Hallucinogen Cognitive psychology |
| Citations | 11 |
| Key findings | Variability in simple perceptual tasks, but not pupil-size increase, is significantly related to the extent of drug-induced psychopathology from psilocybin. |
Abstract
Autonomic, perceptual, and behavioral changes induced by 160 µg/kg psilocybin were studied in a homogenous sample of 15 self-selected College educated male and female volunteers. The subjects were rank ordered as to the extent of drug-induced psychopathology using their Minnesota Multiphasic Personality Inventory pre-drug to drug peak differences scores. Extent of variability on simple perceptual tasks – in gustation and vision – is significantly related to extent of drug-induced psychopathology, whereas drug-induced pupil-size increase – a reliable autonomic variable – is unrelated to drug-induced psychopathology, which, in our terminology, is equated with a subject's symbolic interpretation of his own central nervous System activity.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |