The therapeutic potential of psilocybin: a systematic review
Jan Van Amsterdam, Wim van den Brink
Expert Opinion on Drug Safety February 26, 2022 DOI: 10.1080/14740338.2022.2047929 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Double-blind Peer reviewed |
|---|---|
| Interventions | Psilocybin Psychotherapy |
| Topics | Psilocybin |
| Keywords | Adverse effect Hallucinogen Placebo Randomized controlled trial Clinical trial |
| Citations | 74 |
| Key findings | Psilocybin combined with psychotherapy shows promise for treating mental disorders, but larger double-blind RCTs with long-term outcomes are needed before standard clinical use. |
Abstract
Psilocybin - mostly combined with psychotherapy or psychotherapeutic support - shows a promise as a treatment for various (treatment-resistant) mental disorders. Larger double-blind RCTs with objective (long-term) outcomes are needed to confirm these findings before standard clinical use of psilocybin can be considered.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cited by 44
- Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study Nature Medicine July 24, 2023
- Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications International Journal of Molecular Sciences November 16, 2022
- Psilocybin history, action and reaction: A narrative clinical review Journal of Psychopharmacology August 31, 2023
- Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial Frontiers in Psychiatry April 25, 2023
- Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review Clinical Psychopharmacology and Neuroscience October 16, 2023
and 39 more in the library
Cites 43
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry May 17, 2016
- Trial of Psilocybin versus Escitalopram for Depression New England Journal of Medicine April 14, 2021
- Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer Archives of General Psychiatry September 7, 2010
and 38 more in the library