Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat.
Klemens Egger, Daniel Meling, Firuze Polat, Erich Seifritz, Mihai Avram, Milan Scheidegger
Imaging Neurosci (Camb) September 29, 2025 DOI: 10.1162/imag.a.907 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Adult participants in a meditation retreat |
| Interventions | N N-dimethyltryptamine harmine |
| Topics | 5-MeO-DMT Meditation Neuroplasticity DMT |
| Keywords | Psychedelics Harmine Psychoactive compounds Entheogens Brain connectivity Neural networks Brain communication Brain imaging Brain reorganization Meditative experiences Contemplative practices Spiritual retreats Cognitive enhancement Mental flexibility Psychological benefits Well-being Brain health |
| Citations | 1 |
| Key findings | DMT and harmine administered during a meditation retreat altered resting-state functional connectivity in brain networks associated with self-referential thought and sensory integration, correlating with improved psychological well-being. |
Abstract
Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat.