Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial.
Yuting Li, Hongxiang Li, Feng Zhang, Yumeng Chen, Dong Zhang
Drug Design, Development and Therapy 2025 DOI: 10.2147/DDDT.S520252 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Pilot study Peer reviewed |
|---|---|
| Sample size | 60 |
| Population | Patients with septic shock in the ICU receiving invasive mechanical ventilation |
| Interventions | Esketamine Remifentanil Propofol |
| Duration | 28-day follow-up |
| Topics | Esketamine |
| Keywords | Critical care medicine Invasive mechanical ventilation Norepinephrine Remifentanil Septic shock Sedation protocols Vasopressors |
| Citations | 3 |
| Key findings | Esketamine may decrease the dosage of norepinephrine in patients with septic shock receiving invasive mechanical ventilation. |
Abstract
Analgesics and sedatives may affect the hemodynamics of patients with septic shock and produce adverse reactions. The purpose of this study is to compare the hemodynamic effects and prognosis of esketamine and remifentanil in combination with propofol in patients with septic shock receiving invasive mechanical ventilation. In this single-center, prospective, randomized, controlled pilot study, patients with septic shock in the intensive care unit (ICU) receiving invasive mechanical ventilation were randomized to receive esketamine or remifentanil in combination with propofol intravenously. The target Critical-Care Pain Observation Tool (CPOT) score was 0.05). Kaplan-Meier survival analysis showed that there was no significant difference in 28-day survival rate between the two groups(P=0.225). Esketamine may decrease the dosage of norepinephrine in patients with septic shock receiving invasive mechanical ventilation. It is beneficial for stabilizing hemodynamics and appears to be an effective and safe agent for patients with septic shock requiring invasive mechanical ventilation.