Serotonin, psychedelics and psychiatry
World Psychiatry September 7, 2018 DOI: 10.1002/wps.20555 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | Neuropsychopharmacology Mood Psychoanalysis |
| Citations | 49 |
| Key points | Argues that no compelling unified theory of brain serotonin function has been established, unlike for dopamine, and attributes this to the serotonin system's complexity, including 14 or more receptors, over twice the number identified for any other major neuromodulator system. Notes serotonin's implication in several major psychiatric disorders, most obviously depression. |
Abstract
Serotonin is a key neuromodulator known to be involved in brain development, perception, cognition, and mood. However, unlike as with dopamine for example, a compelling unified theory of brain serotonin function has not yet been established. This is likely due to the exceptional complexity of the serotonin system, with its 14+ receptors, over twice the number identified for any of the other major neuromodulator systems1. Serotonin has been implicated in several major psychiatric disorders, and most obviously in depression.
Citations in the library
Cited by 26
- REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics Pharmacological Reviews June 20, 2019
- Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory. Journal of Psychopharmacology July 11, 2019
- Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness. Frontiers in Pharmacology March 25, 2021
- Pivotal mental states Journal of Psychopharmacology April 1, 2021
- Temporo-spatial Theory of Consciousness (TTC) - Bridging the gap of neuronal activity and phenomenal states. Behavioural Brain Research February 1, 2022
and 21 more in the library
Cites 4
- Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Frontiers in Pharmacology January 17, 2018
- The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future. Neuropsychopharmacology April 26, 2017
- Psychedelics and the essential importance of context. Journal of Psychopharmacology February 15, 2018
- Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology August 31, 2017