Translational Challenges in Psychedelic Medicine.
New England Journal of Medicine February 1, 2023 DOI: 10.1056/nejmcibr2213109 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Keywords | Psychedelic treatments Psychedelic medicine Hallucinogenic treatments Mental health Mental wellness Psychiatric care Psychological health Drug development Pharmaceutical development Clinical trials Regulatory pathways Medical research Drug discovery Healthcare access Patient access Treatment availability Healthcare equity Medical access |
| Citations | 10 |
| Key points | Argues that assumptions implicit in mouse modeling of a 'nonpsychedelic psychedelic' compound cannot be trusted to translate to humans. |
Abstract
A “nonpsychedelic psychedelic” compound was shown to have anxiolytic and antidepressive effects in a mouse model. This commentary asks whether assumptions implicit in mouse modeling can be trusted to translate to humans.
Citations in the library
Cited by 6
- Canalization and plasticity in psychopathology Neuropharmacology December 27, 2022
- UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. Neuropsychopharmacology November 1, 2023
- Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder International Journal of Mental Health and Addiction March 7, 2024
- Low‐dose psilocybin in short‐lasting unilateral neuralgiform headache attacks: results from an open‐label phase Ib ascending dose study Headache: The Journal of Head and Face Pain September 20, 2024
- Disentangling the acute subjective effects of classic psychedelics from their enduring therapeutic properties. Psychopharmacology May 14, 2024
and 1 more in the library
Cites 4
- Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Scientific Reports April 19, 2017
- Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression Frontiers in Pharmacology March 31, 2022
- Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience. Journal of Psychopharmacology January 5, 2022
- Bespoke library docking for 5-HT2A receptor agonists with anti-depressant activity Nature September 28, 2022