Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep.
Jumpei Togawa, Riki Matsumoto, Kiyohide Usami, Masao Matsuhashi, Morito Inouchi, Katsuya Kobayashi, Takefumi Hitomi, Takuro Nakae, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
Cerebral Cortex December 20, 2022 DOI: 10.1093/cercor/bhac079 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 11 |
| Population | Patients with intractable focal epilepsy |
| Keywords | Rem sleep Consciousness Electrocorticography Phase-amplitude coupling Wakefulness |
| Citations | 2 |
| Key findings | Phase-amplitude coupling between slow waves and gamma activities is stronger in the posterior cortical region than in the frontal region during REM sleep and tends to be higher posteriorly during wakefulness. |
Abstract
The spatiotemporal dynamics of interaction between slow (delta or infraslow) waves and fast (gamma) activities during wakefulness and sleep are yet to be elucidated in human electrocorticography (ECoG). We evaluated phase-amplitude coupling (PAC), which reflects neuronal coding in information processing, using ECoG in 11 patients with intractable focal epilepsy. PAC was observed between slow waves of 0.5-0.6 Hz and gamma activities, not only during light sleep and slow-wave sleep (SWS) but even during wakefulness and rapid eye movement (REM) sleep. While PAC was high over a large region during SWS, it was stronger in the posterior cortical region around the temporoparietal junction than in the frontal cortical region during REM sleep. PAC tended to be higher in the posterior cortical region than in the frontal cortical region even during wakefulness. Our findings suggest that the posterior cortical region has a functional role in REM sleep and may contribute to the maintenance of the dreaming experience.
Citations in the library
Cites 9
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and 4 more in the library