Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Devon Stoliker, Leonardo Novelli, Adeel Razi, Franz X. Vollenweider, Gary F. Egan, Katrin H. Preller
Biological Psychiatry January 5, 2024 DOI: 10.1016/j.biopsych.2024.01.002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Amygdala Cognition Resting State FMRI Functional connectivity Cognitive psychology Hallucinogen |
| Citations | 42 |
| Key findings | Temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity, which are significant for altered cognition and perception and suggest targets for psychedelic therapy research. |
Abstract
Our findings suggest that temporary amygdala signal attenuation is associated with mechanistic changes to resting-state network connectivity. These changes are significant for altered cognition and perception and suggest targets for research investigating the efficacy of psychedelic therapy for internalizing psychiatric disorders. More broadly, our study suggests the value of quantifying the brain's hierarchical organization using effective connectivity to identify important mechanisms for basic cognitive function and how they are integrated to give rise to subjective experiences.
Comparable studies
Other observational and cohort studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Patients with treatment-resistant depression | 2017 | Observational cohort | n = 19 |
| Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Healthy volunteers | 2019 | Observational cohort | n = 8 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Prediction of Psilocybin Response in Healthy Volunteers Healthy volunteers | 2012 | Observational cohort | n = 409 |
Citations in the library
Cited by 33
- Potential Differences in Psychedelic Actions Based on Biological Sex. Endocrinology July 1, 2024
- Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry April 1, 2025
- Psilocybin as a novel treatment for chronic pain British Journal of Pharmacology November 29, 2024
- The Emergence of Psilocybin in Psychiatry and Neuroscience Pharmaceuticals April 9, 2025
- Catalyst for change: Psilocybin’s antidepressant mechanisms—A systematic review Journal of Psychopharmacology January 20, 2025
and 28 more in the library
Cites 63
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder JAMA Psychiatry November 4, 2020
- Human hallucinogen research: guidelines for safety. Journal of Psychopharmacology July 1, 2008
and 58 more in the library