Possible mechanism of 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats.
T P Blackburn, B Cox, C G Heapy, T F Lee
Pharmacology, biochemistry, and behavior 1982 DOI: 10.1016/0091-3057(82)90004-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats with unilateral dorsal raphe nucleus lesions |
| Interventions | 5-MeODMT methysergide cyproheptadine cinanserin xylamidine haloperidol hyoscine picrotoxin naloxone strychnine alpha-methyl-p-tyrosine 6-hydroxydopamine |
| Dose | 7.5 mg/kg SC |
| Topics | 5-MeO-DMT DMT |
| Citations | 4 |
| Key findings | 5-MeODMT-induced contralateral turning in DRN-lesioned rats involves a central dopaminergic system. |
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) (7.5 mg/kg SC) caused a contralateral turning in rats with a unilateral lesion of the dorsal raphe nucleus (DRN). This turning behaviour was blocked by pretreatment with putative 5-HT antagonists, methysergide, cyproheptadine and cinanserin. The peripheral 5-HT antagonist, xylamidine, also prevented the response to 5-MeODMT. Of the other neurotransmitter antagonists, only haloperidol was active, hyoscine, picrotoxin, naloxone and strychnine were ineffective. Pretreatment with alpha-methyl-p-tyrosine (alpha-MT) also significantly reduced the turning response to 5-MeODMT. These results indicate that a central dopaminergic system is involved in 5-MeODMT-induced turning behaviour. This suggestion is supported by the finding that an ipsilateral turning in response to 5-MeODMT was observed in the rats with additional 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle (MFB). The possible mechanisms by which 5-MeODMT induced turning in DRN lesioned rats are discussed.