Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats.
Toshitaka Nabeshima, K Ishikawa, K Yamaguchi, H Furukawa, T Kameyama
Neuroscience Letters May 19, 1987 DOI: 10.1016/0304-3940(87)90425-3 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Interventions | Phencyclidine (PCP) 5-methoxy-N N-dimethyltryptamine (5-MeODMT) ritanserin |
| Dose | PCP 7.5, 10 and 12.5 mg/kg i.p.; 5-MeODMT 2 and 4 mg/kg i.p.; ritanserin 1 mg/kg s.c. |
| Topics | Serotonin |
| Citations | 27 |
| Key findings | PCP-induced head-twitch is mediated by 5-HT2 receptors, as it is completely antagonized by ritanserin in both mice and rats. |
Abstract
This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced behavior. PCP (7.5, 10 and 12.5 mg/kg, i.p.)-induced head-twitch was completely antagonized by ritanserin (1 mg/kg, s.c.) in mice and rats, and 5-MeODMT (2 and 4 mg/kg, i.p.)-induced head-twitch was also completely antagonized by ritanserin in mice. PCP and 5-MeODMT induced head-weaving in mice after ritanserin treatment, but this did not occur in rats. In rats, 5-MeODMT failed to induce head-twitch. These results suggest that PCP-induced head-twitch response in rats is developed via 5-HT2 receptors and it is a useful 5-HT2 receptor model, while 5-MeODMT-induced head-weaving in rats is developed via 5-HT1 receptors and is a useful 5-HT1 receptor model.
Comparable studies
Other preclinical and animal studies on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo Mice | 2021 | Observational cohort | |
| Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Rats (implied by typical neurochemical study context) | 1987 | Experimental study | |
| Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors In vitro and in vivo (rodent) models | 2023 | Experimental study | |
| 3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites. Rat brain | 1987 | Animal experiment | |
| Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs Human and mouse dopamine, norepinephrine, and serotonin transporters expressed in cells | 2006 | In vitro laboratory study |
Citations in the library
Cited by 8
- New Paradigms of Old Psychedelics in Schizophrenia Pharmaceuticals May 23, 2022
- Probing the antidepressant potential of psilocybin: integrating insight from human research and animal models towards an understanding of neural circuit mechanisms. Psychopharmacology 2023
- Psychotomimetic compensation versus sensitization. Pharmacology Research & Perspectives August 1, 2024
- Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration Translational Psychiatry June 13, 2025
- D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI Behavioural Brain Research November 20, 2013
and 3 more in the library