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Chemical and enzymatic oxidative coupling of 5-hydroxy-N,N-dimethyltryptamine with amines.

F Babin, T Huynh-Dinh

Journal of Medicinal Chemistry July 1, 1987 DOI: 10.1021/jm00390a020 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Topics 5-MeO-DMT DMT
Citations 13
Key findings Oxidation of bufotenine followed by Michael addition with amino compounds yields a fluorescent fused oxazole adduct.

Abstract

As part of a program aiming to obtain a covalent labeling of serotoninergic receptors we have studied the oxidative coupling of serotonin derivatives with amino compounds. The oxidation of bufotenine (2) by MnO2 and human ceruloplasmin followed by the Michael type addition with dansylcadaverine and dansyllysine gave a fluorescent adduct identified as fused oxazole structure 4.

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