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The anxiolytic-like effect of the alkaloid fraction of the psychedelic plant Mimosa tenuiflora (Willd.) Poir.

Jady Vitoria Barjud Pereira Ferreira, Ana Marcia de Freitas Pessoa, Rita de Cassia de Lima Sousa, Carlos Mario Freitas de Oliveira, Laryssa Gomes Eulálio, Renato Pinto de Sousa, Gerardo Magela Vieira Júnior, Victor de Jesus Silva Meireles, Daniel Dias Rufino Arcanjo, Maurício Pires de Moura do Amaral

Natural Product Research September 18, 2024 DOI: 10.1080/14786419.2024.2405875 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Controlled experiment Peer reviewed
Population Female Swiss mice, 6 weeks old
Intervention Diazepam
Dose AF II 6 mg/kg; diazepam 5 mg/kg
Topics DMT
Keywords Hplc Mimosa tenuiflora Anxiolytic Elevated plus-maze test Light-dark box test
Citations 1
Key findings The alkaloid fraction AF II from Mimosa tenuiflora root bark shows significant anxiolytic effects in the light-dark box and elevated plus maze tests in mice.

Abstract

The present work investigated the anxiolytic effect of the alkaloid fraction (AF II) from the root bark of Mimosa tenuiflora. Female Swiss mice of 6 weeks old were used in this study. The animals were divided into three groups: 0.9% NaCl (vehicle group, s.c.), AF II (6 mg/kg, s.c.), and diazepam - DZP (5 mg/kg, s.c.). The light/dark box and elevated plus maze tests evaluated the animal anxiety. DMT was identified by the HPLC method. AF II showed significant anxiolytic effects in the two behavioural tests used.

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