Time-dependent interactions between iboga agents and cocaine.
Isabelle M Maisonneuve, K E Visker, G L Mann, Upul K. Bandarage, Martin E. Kuehne, Stanley D Glick
European Journal of Pharmacology October 8, 1997 DOI: 10.1016/s0014-2999(97)01231-4 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Ibogaine Noribogaine 18-Methoxycoronaridine |
| Dose | 40 mg/kg |
| Duration | 3 hours of motor activity monitoring after cocaine administration |
| Topics | Ibogaine |
| Citations | 20 |
| Key findings | Ibogaine, noribogaine, and 18-methoxycoronaridine acutely inhibit and later potentiate cocaine-induced hyperactivity in rats. |
Abstract
The purpose of this study was to clarify the effects of iboga agents on cocaine-induced hyperactivity. Both inhibition and enhancement of cocaine-induced activity by ibogaine have been reported. In the present study, rats were treated with either ibogaine (40 mg/kg, i.p.), noribogaine (40 mg/kg, i.p.), 18-methoxycoronaridine (40 mg/kg, i.p.), or saline, 1 or 19 h prior to the administration of cocaine (20 mg/kg, i.p.) or saline. Motor activity was monitored thereafter for 3 h. All three iboga agents had acute inhibitory effects and delayed potentiating effects on cocaine-induced hyperactivity. These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature.