The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus.
Scott Helsley, R A Rabin, Jerrold C Winter
European Journal of Pharmacology March 19, 1998 DOI: 10.1016/s0014-2999(98)00002-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | ibogaine harmaline 6-methoxyharmalan harmine harmane harmalol tetrahydro-beta-carboline norharmane DMCM |
| Topics | Ibogaine |
| Keywords | Ibogaine: ibogaine effects Ibogaine-like effect Beta-carbolines: natural compounds 6-methoxyharmalan Harmine Internal sensations Drug identification Drug mimicry Drug similarity Neuropharmacology: brain training Investigated |
| Citations | 6 |
| Key points | 6-Methoxyharmalan fully substituted for ibogaine as a discriminative stimulus in rats, while other beta-carbolines showed partial or no substitution. |
Abstract
The structural features and hallucinogenic properties shared by ibogaine and certain beta-carbolines prompted the evaluation of several representative beta-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-beta-carboline (THBC). Norharmane and 6,7-dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 4
- Ibogaine and Noribogaine: Comparing Parent Compound to Metabolite CNS Drug Reviews September 1, 2000
- Drug discrimination studies with ibogaine. The Alkaloids: Chemistry and Biology 2001
- État des lieux de la recherche sur les capacités thérapeutiques des « substances hallucinogènes » au 21 e siècle Psychotropes April 23, 2018
- Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug and Alcohol Dependence August 1, 2000
Cites 12
- Effects and aftereffects of ibogaine on morphine self-administration in rats. European Journal of Pharmacology April 3, 1991
- Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research September 19, 1994
- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
- Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies. Brain Research February 7, 1992
and 7 more in the library