Stimulus effects of three sulfur-containing psychoactive agents.
Nantaka Khorana, Manik R Pullagurla, Małgorzata Dukat, Richard Young, Richard A Glennon
Pharmacology, Biochemistry, and Behavior August 1, 2004 DOI: 10.1016/j.pbb.2004.05.021 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Drug discrimination task Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 4-MTA 4-MTMA 2C-T-7 |
| Topics | MDMA |
| Keywords | Emerging sulfur-containing compounds Categorizing these substances Distinct effects Mimicked MDMA'S Effects Subjective impact Psychoactive properties Rats Investigation Hallucinogen Stimulant Empathogen Dom Cocaine 4-mta 4-mtma 2c-t-7 |
| Citations | 21 |
| Key points | 4-MTA and 4-MTMA substituted only for the MDMA stimulus, while 2C-T-7 substituted only for the DOM stimulus. |
Abstract
Two agents gaining popularity on the illicit drug market are the phenylalkylamines 4-MTA and 2C-T-7 [or 1-(4-methylthiophenyl)-2-aminopropane and 2-(2,5-dimethoxy-4-n-propylthiophenyl)-1-aminoethane, respectively]. At this time, there exists a paucity of information on the behavioral actions of these sulfur-containing agents. The present investigation examined these agents, and the N-monomethyl analog of 4-MTA (i.e., 4-MTMA), in tests of stimulus generalization (substitution) using a two-lever drug discrimination task with groups of rats trained to discriminate either the hallucinogen DOM [1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane], the stimulant cocaine, or the empathogen MDMA from vehicle. 4-MTA and its N-monomethyl analog 4-MTMA (ED50 = 0.8 mg/kg in both cases) substituted only for the MDMA stimulus, whereas 2C-T-7 (ED50 = 0.8 mg/kg) substituted only for the DOM stimulus. Thus, at the doses examined, 4-MTA and 4-MTMA appear to be MDMA-like agents, and 2C-T-7 seems best classified as a DOM-like hallucinogen. These results provide additional data that extend the structure-activity relationships of phenylalkylamines and that are consistent with what little is currently known about the action of 4-MTA and 2C-T-7 in humans.
Comparable studies
Other preclinical and animal studies on MDMA, most cited first.
Citations in the library
Cited by 9
- Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats. Psychopharmacology September 1, 2005
- MDMA Self-Administration in Laboratory Animals: A Summary of the Literature and Proposal for Future Research Neuropsychobiology 2009
- New trends in the cyber and street market of recreational drugs? The case of 2C-T-7 ('Blue Mystic'). Journal of Psychopharmacology November 1, 2005
- Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology January 15, 2007
- MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology Current Neuropharmacology August 1, 2013
and 4 more in the library
Cites 4
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- Effect of 1-(3,4-methylenedioxyphenyl)-2-aminopropane and its optical isomers in PMMA-trained rats. Pharmacology, Biochemistry, and Behavior May 2002
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- Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists. European Journal of Pharmacology July 1, 1983