Acute ibogaine injection induces expression of the immediate early genes, egr-1 and c-fos, in mouse brain.
S F Ali, Nathalie Thiriet, Jean Zwiller
Brain research. Molecular brain research December 10, 1999 DOI: 10.1016/s0169-328x(99)00283-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Adult male C57 mice |
| Intervention | Ibogaine |
| Duration | 30 minutes after injection |
| Topics | Ibogaine |
| Keywords | Psychoactive compound Psychedelic Gene expression Genetic activation Gene activity Egr-1 C-fos Molecular biology Genomics Brain research Neurobiology Brain activity Nucleus accumbens Frontal cortex Hippocampus Psychostimulants Stimulant effects Psychoactive drugs Drug effects |
| Citations | 13 |
| Key findings | A single acute injection of ibogaine induces immediate early gene expression (egr-1 and c-fos) in multiple brain regions of mice, possibly related to its stimulant properties. |
Abstract
The aim of the present study was to evaluate if an acute injection of ibogaine (IBO) induces immediate early gene expression in different regions of mouse brain. Adult male C57 mice received a single injection of IBO and were perfused transcardially with 1% paraformaldehyde 30 min after the drug administration. A single injection of IBO produced a significant increase of egr-1 messenger RNA induction in nucleus accumbens (NAc), caudate-putamen (CPu), frontal cortex (FCx), septum, dentate gyrus (DG) and CA3 region of hippocampus, whereas c-fos gene was induced in CPu, FCx, DG, septum and CA1 region of hippocampus. This gene expression may be due, in part, to the stimulant properties of IBO, as we found with other psychostimulants.