Noribogaine reduces nicotine self-administration in rats.
Qing Chang, Taleen Hanania, Deborah C. Mash, Émeline L. Maillet
Journal of psychopharmacology (Oxford, England) June 1, 2015 DOI: 10.1177/0269881115584461 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Within-subject design with a Latin square test schedule Peer reviewed |
|---|---|
| Population | Adult male Sprague-Dawley rats |
| Interventions | Noribogaine varenicline |
| Dose | 12.5, 25 or 50 mg/kg orally |
| Duration | 26 sessions of nicotine self-administration training |
| Topics | Addiction Ibogaine |
| Keywords | Food self-administration Nicotine addiction treatment Noribogaine pharmacology Behavioral specificity |
| Citations | 26 |
| Post-publication review | 2 comments on PubPeer (opens in new tab) · last active September 2016 |
| Key points | Noribogaine dose-dependently decreased nicotine self-administration by up to 64% and was equi-effective to varenicline, with less effect on food self-administration. |
Abstract
Noribogaine, a polypharmacological drug with activities at opioid receptors, ionotropic nicotinic receptors, and serotonin reuptake transporters, has been investigated for treatment of substance abuse-related disorders. Smoking cessation has major benefits for both individuals and society, therefore the aim of this study was to evaluate the potential of noribogaine for use as a treatment for nicotine dependence. Adult male Sprague-Dawley rats were trained to self-administer nicotine intravenous. After initial food pellet training, followed by 26 sessions of nicotine self-administration training, the rats were administered noribogaine (12.5, 25 or 50 mg/kg orally), noribogaine vehicle, varenicline or saline using a within-subject design with a Latin square test schedule. Noribogaine dose-dependently decreased nicotine self-administration by up to 64% of saline-treated rats' levels and was equi-effective to 1.7 mg/kg intraperitoneal varenicline. Noribogaine was less efficient at reducing food pellets self-administration than at nicotine self-administration, inhibiting the nondrug reinforcing effects of palatable pellets by 23% at the highest dose. These results suggest that noribogaine dose-dependently attenuates drug-taking behavior for nicotine, attenuates the reinforcing effects of nicotine and is comparable to varenicline power in that regard. The findings from the present study hold promise for a new therapy to aid smoking cessation.
Comparable studies
Other preclinical and animal studies on ibogaine for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study | |
| Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Morphine-dependent rats | 1992 | Randomized controlled trial | |
| Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Dopaminergic-like SHSY5Y cell line | 2006 | In vitro cell culture study | |
| A dose-response study of ibogaine-induced neuropathology in the rat cerebellum. Rats | 2000 | Dose-response study | n = 30 |
| Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents. Mice and rats | 2016 | Experimental study with three experiments |
Citations in the library
Cited by 10
- DARK Classics in Chemical Neuroscience: Ibogaine ACS Chemical Neuroscience September 14, 2018
- Noribogaine is a G-protein biased κ-opioid receptor agonist. Neuropharmacology December 1, 2015
- IUPHAR - invited review - Ibogaine - A legacy within the current renaissance of psychedelic therapy. Pharmacological Research April 1, 2023
- Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents. Journal of psychopharmacology (Oxford, England) July 1, 2016
- Anxiolytic-like effects of noribogaine in zebrafish. Behavioural Brain Research July 14, 2017
and 5 more in the library
Cites 15
- Treatment of acute opioid withdrawal with ibogaine. The American Journal on Addictions 1999
- Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures. Annals of the New York Academy of Sciences September 1, 2000
- Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacology, biochemistry, and behavior November 1, 1995
- 18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats. Brain Research May 6, 1996
- Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependencea. Annals of the New York Academy of Sciences May 1, 1998
and 10 more in the library