Default mode network

Argues that hypnotic states modulate the DMN, executive control, and salience networks to reorganize emotional experience and self-referential processing, supporting a mechanistic model of emotion regulation and self-integration.

integrative review

Psilocybin reduces depressive symptoms with large effect sizes and durable benefits up to one year, with neuroimaging showing modifications within default mode and executive networks.

review

Psychedelic-assisted therapy, through 5-HT2A agonism and DMN disintegration, shows significant therapeutic potential for TRD, existential distress, and substance use disorders.

systematic review

Presents a new fMRI-based technique for measuring excitatory/inhibitory balance in MS, addressing a gap in existing methods, but does not report specific DMN findings.

observational

Argues that the reflective self is underpinned by DMN activity, while the experiential self is supported by salience network hubs, proposing a dual-self framework for consciousness.

theoretical or philosophical paper

Argues that the self is a dynamic, distributed network centered on the DMN, not a fixed entity, based on philosophical accounts and neuroscience.

theoretical or philosophical paper

Psilocybin led to significant OCD symptom reduction (23% to 100% improvement) with no severe side effects, and the abstract notes a hyperfunctioning DMN in OCD.

randomized placebo-controlled trial

Aims to map neurobiological evidence for PTSD interventions within the triple-network model (DMN, salience, central executive), but no results are reported in the abstract.

scoping review

Argues that psychedelics increase functional integration across brain networks while weakening DMN stability, and proposes extending research to organism-wide coherence.

theoretical or philosophical paper

Proposes that tranquil states are characterized by co-attenuation of DMN activity and salience-network drive, distinct from trait effects.

theoretical or philosophical paper

Each meditation style produced specific directed connectivity changes relative to rest, with focused attention reducing bottom-up influences, open monitoring increasing left-to-right posterior modulation, and loving kindness showing interhemispheric symmetry.

observational study Sample size: 22

Argues that combining rTMS with mindfulness may enhance outcomes for TRD by leveraging shared network targets including the DMN.

review

Argues that addiction involves alterations in the DMN, limbic dysregulation, and reduced top-down control, with oceanic states as transitional phenomena.

theoretical or philosophical paper

Poor surgical outcome was associated with heightened DMN-limbic hyperconnectivity, indicating maladaptive central reorganization.

prospective nested case-control study Sample size: 60

ASMR trigger listening increased functional connectivity between medial prefrontal cortex and right lateral parietal cortex (DMN regions) compared to classical music.

observational cohort Sample size: 48

DMN activity persists in isolated hemispheres, meeting a necessary condition for consciousness, but does not alone confirm conscious awareness.

prospective case-control study Sample size: 50

External-attention ratings were lower for trials triggered by posteromedial cortex (DMN) activation, supporting the link between DMN activity and internally focused thought.

proof-of-concept study Sample size: 60

Argues that self-referential evaluative monitoring regulates transitions between System 1 and System 2 by modulating DMN activity and quantum coherence.

theoretical or philosophical paper