June 2026
Ayahuasca
What June 2026's 6 new studies found, synthesized from the papers below. All Ayahuasca research →
The synthesis
Synthesized from 6 studies in the library · AI-generated, grounded in the abstracts below
Found by searching the library for Ayahuasca, yage, hoasca, banisteriopsis, then ranked by relevance.
Research on ayahuasca published in June 2026 shows that the brew induces profound alterations in perception and self-referential processing, which are linked to changes in brain connectivity, neurochemistry, and peripheral metabolism. However, the evidence is limited to a single within-subject study with a small sample of experienced users, and no clinical trials or systematic reviews specifically on ayahuasca were published in this period. The main caveat is the lack of controlled, generalizable data on therapeutic efficacy or long-term effects.
Evidence by study
Direction is which way each study's own result points, not our rating of the study.
What the directions mean
- Supports:
- the study found the intervention worked, or its hypothesis held.
- Opposes:
- it found the opposite, no benefit or a harm.
- No effect:
- no significant difference either way.
- Mixed:
- effects in both directions within the same study.
- Unclear:
- the abstract does not report a direction.
| Study | Design | Sample size | Direction | Finding |
|---|---|---|---|---|
| Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations. 2026 | review | Unclear | This review covers psychedelics for TRD but does not specifically address ayahuasca; it focuses on psilocybin, ketamine, and esketamine. | |
| Global pressure on ayahuasca threatens Amazonian plants and knowledge systems 2026 | commentary | Unclear | This commentary warns that global pressure on ayahuasca threatens Amazonian plants and Indigenous knowledge systems. | |
| EXPANSÃO GLOBAL DA AYAHUASCA E SAÚDE MENTAL 2026 | theoretical review | Unclear | This theoretical review discusses the global expansion of ayahuasca, its psychotherapeutic potentials, and psychosocial challenges, emphasizing the need for interdisciplinary care and respect for Indigenous knowledge. | |
| Koshering Psychedelics: Ayahuasca in the Ultra-Orthodox (Haredi) Jewish World 2026 | qualitative | 23 | Mixed | This qualitative study found that Haredi ayahuasca use was primarily therapeutic, led to strengthened religious belief and practice, but also created religious tensions around foreignness, idolatry, and authority. |
| Beliefs in and experiences of sorcery, black magic and brujería among psychedelic users: a quantitative and qualitative survey 2026 | cross-sectional survey | 895 | Unclear | This survey examines beliefs in sorcery and supernatural harm among psychedelic users, but does not report specific findings on ayahuasca's effects. |
| Brain-body integromics of the ayahuasca experience. 2026 | within-subject experimental | 20 | Supports | This integrative study found that ayahuasca-induced subjective experiences (oceanic boundlessness, visionary restructuralization, auditory alterations) covaried with plasma DMT and β-carbolines, changes in lipid/amino acid/energy metabolism, and reconfiguration of dorsal attention and default mode network connectivity. |
This review covers psychedelics for TRD but does not specifically address ayahuasca; it focuses on psilocybin, ketamine, and esketamine.
review
This commentary warns that global pressure on ayahuasca threatens Amazonian plants and Indigenous knowledge systems.
commentary
This theoretical review discusses the global expansion of ayahuasca, its psychotherapeutic potentials, and psychosocial challenges, emphasizing the need for interdisciplinary care and respect for Indigenous knowledge.
theoretical review
This qualitative study found that Haredi ayahuasca use was primarily therapeutic, led to strengthened religious belief and practice, but also created religious tensions around foreignness, idolatry, and authority.
qualitative Sample size: 23
This survey examines beliefs in sorcery and supernatural harm among psychedelic users, but does not report specific findings on ayahuasca's effects.
cross-sectional survey Sample size: 895
This integrative study found that ayahuasca-induced subjective experiences (oceanic boundlessness, visionary restructuralization, auditory alterations) covaried with plasma DMT and β-carbolines, changes in lipid/amino acid/energy metabolism, and reconfiguration of dorsal attention and default mode network connectivity.
within-subject experimental Sample size: 20
Points of agreement
- Ayahuasca use is associated with altered states of consciousness and subjective experiences that are shaped by cultural and religious context.
- There is growing concern about the global expansion of ayahuasca and its impact on Indigenous knowledge and ecosystems.
Conflicts
- No direct conflicts among the studies, as they address different aspects (neurobiology, cultural adaptation, ecological threat) and use different methodologies.
Gaps
- No clinical trials or controlled studies on ayahuasca's therapeutic efficacy were published in June 2026.
- The neurobiological study (28189) had a small sample (N=20) and no control group, limiting generalizability.
- Long-term effects, dose-response relationships, and safety in diverse populations remain unstudied.
- No studies examined ayahuasca's effects in treatment-resistant depression or other clinical populations in this period.